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We found that therapeutic doses decrease liver GSH by only modest amounts (10%), but that overdoses of 10 grams or more severely deplete liver GSH (Figure6)

For the GSH function experimental group, dorsal shaved mice were intraperitoneally injected with 100 mg/kg (body weight) of reduced GSH (G8180, Solebo, China) and 450 mg/kg (body weight) of BSO (HY-106376, MCE, China), while the control group was treated by phosphate-buffered saline (PBS) (T8166, Taojiao, China) or dimethyl sulfoxide (BS087-100 ml, Biosharp, China)

What Causes Low Glutathione Levels